lasmiditan, diazepam. Possibly increases outcomes of one other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, together with alcohol haven't been evaluated in clinical scientific studies. Lasmiditan might lead to sedation, in addition to other cognitive and/or neuropsychiatric adverse reactions.
As a consequence of long-acting metabolite, not considered a drug of alternative within the aged; related to falls
Diazepam is the most common benzodiazepine used in dogs and cats to reduce motor exercise and permit placement of an IV catheter.
lemborexant, diazepam. Possibly boosts outcomes of the opposite by sedation. Modify Therapy/Keep track of Closely. Dosage adjustment can be important if lemborexant is coadministered with other CNS depressants for the reason that of probably additive effects.
diltiazem will increase the amount or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
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Reserve concomitant prescribing of such drugs in patients for whom other remedy selections are inadequate. Restrict dosages and durations into the least demanded. Observe closely for indications of respiratory melancholy and sedation.
fentanyl intranasal and diazepam both of those improve sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom choice cure selections are insufficient
nilotinib will raise the amount or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
scopolamine decreases effects of secretin by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation tests with secretin. Discontinue anticholinergic drugs at least 5 half-lives prior to administering secretin.
Acute intoxication with Liquor, narcotics, or other psychoactive substances (apart from hallucinogens or some stimulants, where by it is sometimes used as being a therapy for overdose)
sage decreases effects of diazepam by pharmacodynamic antagonism. Slight/Importance Mysterious. Theoretical conversation; some species of sage might lead to convulsions.
Position client on side going through you with higher leg bent forward, lubricate rectal applicator suggestion, Carefully insert syringe tip in rectum and bit by bit drive plunger
There are postmarketing experiences of coma and Demise with coadministration of buprenorphine and benzodiazepines. In several, but not these instances, buprenorphine was misused by self-injection. If a benzodiazepine need to be utilized for an indication other than seizures, decrease the benzodiazepine Preliminary dose and go right here cautiously titrate to medical response.